Inducible ablation of dopamine D2 receptors in adult mice impairs locomotion, motor skill learning and leads to severe parkinsonism

Motor execution and planning are tightly regulated by dopamine D1 and D2 receptors present in basal ganglia circuits. Although stimulation of D1 receptors is known to enhance motor function, the global effect of D2 receptor (D2R) stimulation or blockade remains highly controversial, with studies sho...

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Detalles Bibliográficos
Autores principales: Bello, E.P., Casas-Cordero, R., Galiñanes, G.L., Casey, E., Belluscio, M.A., Rodríguez, V., Noaín, D., Murer, M.G., Rubinstein, M.
Formato: JOUR
Materias:
dopamine 2 receptor
dopamine 1 receptor
dopamine receptor blocking agent
adult
aged
animal experiment
animal model
Article
body posture
catatonia
controlled study
gene mutation
locomotion
male
motor coordination
motor dysfunction
motor learning
mouse
neurologic gait disorder
nonhuman
parkinsonism
phenotype
tremor
ablation therapy
animal
basal ganglion
corpus striatum
drug effects
genetics
human
knockout mouse
learning
metabolism
motor activity
motor performance
pathophysiology
physiology
procedures
Ablation Techniques
Animals
Basal Ganglia
Corpus Striatum
Dopamine Antagonists
Humans
Learning
Locomotion
Male
Mice
Mice, Knockout
Motor Activity
Motor Skills
Parkinsonian Disorders
Receptors, Dopamine D1
Receptors, Dopamine D2
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_13594184_v22_n4_p595_Bello
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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