Regulation of the 11β-hydroxysteroid dehydrogenase in the rat adrenal: Decrease enzymatic activity induced by ACTH

Patients with ectopic ACTH syndrome often develop hypertension and hypokalemic alkalosis with an abnormal increase in the ratio of plasma cortisol to cortisone, indicating that 11β-hydroxysteroid dehydrogenase (11βHSD) activity is inhibited. Inhibition of 11βHSD allows access of cortisol or corticos...

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Detalles Bibliográficos
Autores principales: Morita, H., Cozza, E.N., Zhou, M.-Y., Gomez-Sanchez, E.P., Romero, D.G., Gomez-Sanchez, C.E.
Formato: JOUR
Materias:
11β-hydroxysteroid dehydrogenase
ACTH
Ectopic ACTH syndrome
Rat adrenals
11beta hydroxysteroid dehydrogenase
corticotropin receptor
adrenal gland
animal cell
article
corticosterone release
ectopic corticotropin production
enzyme localization
enzyme regulation
nonhuman
priority journal
rat
zona fasciculata
11-beta-Hydroxysteroid Dehydrogenases
Adrenocorticotropic Hormone
Animals
Calcium
Corticosterone
Depression, Chemical
Enzyme-Linked Immunosorbent Assay
Hydroxysteroid Dehydrogenases
Kinetics
Male
Rats
Rats, Sprague-Dawley
Zona Fasciculata
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_1355008X_v7_n3_p331_Morita
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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