Enhanced LH action in transgenic female mice expressing hCGβ-subunit induces pituitary prolactinomas; the role of high progesterone levels

The etiology of pituitary adenomas remains largely unknown, with the exception of involvement of estrogens in the formation of prolactinomas. We have examined the molecular pathogenesis of prolactin-producing pituitary adenomas in transgenic female mice expressing the human choriongonadotropin (hCG)...

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Detalles Bibliográficos
Autores principales: Ahtiainen, P., Sharp, V., Rulli, S.B., Rivero-Müller, A., Mamaeva, V., Röyttä, M., Huhtaniemi, I.
Formato: JOUR
Materias:
bromocriptine
chorionic gonadotropin beta subunit
cyclin D1
cyclin dependent kinase 4
estradiol
luteinizing hormone
mifepristone
progesterone
retinoblastoma protein
tamoxifen
transcription factor E2F1
prolactin
animal cell
animal experiment
animal model
article
cell culture
controlled study
female
gonadectomy
histology
hypophysis tumor
immunohistochemistry
mouse
nonhuman
ovary
progesterone release
prolactinoma
radioimmunoassay
rat
reverse transcription polymerase chain reaction
transgenic mouse
tumor growth
analysis of variance
animal
blood
cell proliferation
cytology
genetics
hypophysis
metabolism
Analysis of Variance
Animals
Cell Proliferation
Cells, Cultured
Chorionic Gonadotropin, beta Subunit, Human
Cyclin-Dependent Kinase 4
Female
Luteinizing Hormone
Mice
Mice, Transgenic
Pituitary Gland
Pituitary Neoplasms
Progesterone
Prolactin
Prolactinoma
Radioimmunoassay
Reverse Transcriptase Polymerase Chain Reaction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_13510088_v17_n3_p611_Ahtiainen
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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