Curcumin acts as anti-tumorigenic and hormone-suppressive agent in murine and human pituitary tumour cells in vitro and in vivo

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Curcumin (diferuloylmethane) is the active ingredient of the spice plant Curcuma longa and has been shown to act anti-tumorigenic in different types of tumours. Therefore, we have studied its effect in pituitary tumour cell lines and adenomas. Proliferation of lactosomatotroph GH3 and somatotroph Mt...

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Detalles Bibliográficos
Autores principales: Schaaf, C., Shan, B., Buchfelder, M., Losa, M., Kreutzer, J., Rachinger, W., Stalla, G.K., Schilling, T., Arzt, E., Perone, M.J., Renner, U.
Formato: JOUR
Materias:
7 aminodactinomycin
caspase 3
cell cycle protein
curcumin
cyclin D1
cyclin dependent kinase 4
cyclin dependent kinase inhibitor 1B
lipocortin 5
protein bcl 2
antineoplastic activity
apoptosis
article
cancer cell culture
cancer inhibition
cell cycle arrest
cell cycle G2 phase
cell cycle M phase
cell proliferation
cell strain GH3
clinical article
colony formation
controlled study
Curcuma longa
DNA fragmentation
fluorescence activated cell sorting
human
human cell
hypophysis cell
hypophysis tumor
immunoblotting
in vitro study
in vivo study
mouse
nonhuman
nude mouse
Animals
Antineoplastic Agents
Apoptosis
Blotting, Western
Caspase 3
Cell Cycle
Cell Line, Tumor
Cell Proliferation
Curcumin
Cyclin D1
Cyclin-Dependent Kinase 4
Flow Cytometry
Humans
Male
Mice
Mice, Nude
Pituitary Hormones
Pituitary Neoplasms
Rats
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_13510088_v16_n4_p1339_Schaaf
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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