In vivo hemin conditioning targets the vascular and immunologic compartments and restrains prostate tumor development

Purpose: Conditioning strategies constitute a relatively unexplored and exciting opportunity to shape tumor fate by targeting the tumor microenvironment. In this study, we assessed how hemin, a pharmacologic inducer of heme oxygenase-1 (HO-1), has an impact on prostate cancer development in an in vi...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jaworski, F.M., Gentilini, L.D., Gueron, G., Meiss, R.P., Ortiz, E.G., Berguer, P.M., Ahmed, A., Navone, N., Rabinovich, G.A., Compagno, D., Laderach, D.J., Vazquez, E.S.
Formato: JOUR
Materias:
galectin 1
heme oxygenase 1
hemin
angiogenesis
animal cell
animal experiment
animal model
animal tissue
antigen specificity
antineoplastic activity
Article
cancer inhibition
CD8+ T lymphocyte
controlled study
culture medium
cytotoxicity
degranulation
gene expression
histopathology
human
human tissue
immune response
immunosuppressive treatment
in vitro study
in vivo study
lymphocyte proliferation
male
model
mouse
neovascularization (pathology)
nonhuman
priority journal
prostate tumor
tumor immunity
tumor microenvironment
tumor vascularization
tumor xenograft
umbilical vein endothelial cell
animal
antagonists and inhibitors
cell proliferation
disease model
drug effect
drug screening
gene expression regulation
genetics
pathology
Animals
CD8-Positive T-Lymphocytes
Cell Proliferation
Disease Models, Animal
Galectin 1
Gene Expression Regulation, Neoplastic
Heme Oxygenase-1
Hemin
Human Umbilical Vein Endothelial Cells
Humans
Male
Mice
Neovascularization, Pathologic
Prostatic Neoplasms
Xenograft Model Antitumor Assays
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10780432_v23_n17_p5135_Jaworski
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares