Administration of the anesthetic isoflurane to mice: A model for acute intermittent porphyria?

The effects of isoflurane, a commonly used volatile anesthetic, on the activity of some haem enzymes in liver, kidney, and blood, and glucose content in liver and blood were studied. Mice were injected with different doses of the drug (0.5-6 mL/kg) and killed at varying intervals after injection (5-...

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Detalles Bibliográficos
Autores principales: Buzaleh, A.M., de Salamanca, R.E., Del Carmen Batlle, A.M.
Formato: JOUR
Materias:
Acute Intermittent Porphyria
Anesthesia
Isoflurane
5 aminolevulinate synthase
glucose
heme oxygenase
inhalation anesthetic agent
isoflurane
porphobilinogen deaminase
porphobilinogenase
unclassified drug
acute intermittent porphyria
anesthesia
animal experiment
animal model
animal tissue
article
blood
controlled study
dose time effect relation
enzyme activity
glucose metabolism
heme synthesis
intraperitoneal drug administration
kidney
liver
mouse
nonhuman
priority journal
Animal
Disease Models, Animal
Dose-Response Relationship, Drug
Enzyme Activation
Glucose
Kidney
Liver
Mice
Porphyria, Acute Intermittent
Support, Non-U.S. Gov't
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10568719_v28_n4_p191_Buzaleh
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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