QSAR studies of indoyl aryl sulfides and sulfones as reverse transcriptase inhibitors

The inhibitory HIV reverse transcriptase activity of 172 non-nucleoside indoyl aryl sulfones and sulfides is studied with a QSAR analysis, in order to identify the molecular characteristics influencing the interaction with the reverse transcriptase enzyme. This work increases the available QSAR stud...

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Detalles Bibliográficos
Autores principales: Duchowicz, P.R., Bacelo, D.E., Fioressi, S.E., Palermo, V., Ibezim, N.E., Romanelli, G.P.
Formato: JOUR
Materias:
CORAL
HIV reverse transcriptase inhibitors
Indoyl aryl sulfides and sulfones
PaDEL
QSAR
indoyl aryl sulfide
indoyl aryl sulfone
RNA directed DNA polymerase inhibitor
sulfone derivative
unclassified drug
Article
cell differentiation
conformation
controlled study
EC50
enzyme activity
human
Human immunodeficiency virus 1
hydrogen bond
in vitro study
physical chemistry
quantitative structure activity relation
T lymphocyte
validation process
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10542523_v27_n2_p420_Duchowicz
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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