Antiviral activity of an N-allyl acridone against dengue virus

Background: Dengue virus (DENV), a member of the family Flaviviridae, is at present the most widespread causative agent of a human viral disease transmitted by mosquitoes. Despite the increasing incidence of this pathogen, there are no antiviral drugs or vaccines currently available for treatment or...

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Detalles Bibliográficos
Autores principales: Mazzucco, M.B., Talarico, L.B., Vatansever, S., Carro, A.C., Fascio, M.L., D'Accorso, N.B., García, C.C., Damonte, E.B.
Formato: JOUR
Materias:
Acridone
Antiviral
Dengue virus
Re-emerging infection
RNA synthesis
10 allyl 7 chloro 9(10h) acridone
acridone derivative
antivirus agent
cell enzyme
cell protein
guanosine
nicotinamide adenine dinucleotide
unclassified drug
virus protein
virus RNA
allyl compound
animal cell
antiviral activity
antiviral susceptibility
Article
cell metabolism
cell viability
concentration response
controlled study
dengue
Dengue virus 1
Dengue virus 2
Dengue virus 3
Dengue virus 4
drug efficacy
drug mechanism
female
HeLa cell line
host cell
human
human cell
hydrogen bond
in vitro study
molecular docking
nonhuman
priority journal
protein conformation
protein expression
real time polymerase chain reaction
reverse transcription polymerase chain reaction
RNA replication
Vero cell line
virion
virogenesis
virus attachment
virus entry
virus infectivity
virus inhibition
virus replication
drug effects
metabolism
Flaviviridae
Acridones
Allyl Compounds
Antiviral Agents
Dengue Virus
RNA, Viral
Virus Replication
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_10217770_v22_n1_p_Mazzucco
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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