Synthesis and activity evaluation of a series of cholanamides as modulators of the liver X receptors

The Liver X receptors (LXRs) are members of the nuclear receptor family, that play fundamental roles in cholesterol transport, lipid metabolism and modulation of inflammatory responses. In recent years, the synthetic steroid N,N-dimethyl-3β-hydroxycholenamide (DMHCA) arised as a promising LXR ligand...

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Detalles Bibliográficos
Autores principales:	Martínez, M.D., Ghini, A.A., Dansey, M.V., Veleiro, A.S., Pecci, A., Alvarez, L.D., Burton, G.
Formato:	JOUR
Materias:	DMHCA Liver X receptors Molecular dynamics Steroid amides 19 acetoxy 2alpha,3alpha epoxy 5ah cholanic acid methyl ester 19 acetoxy 5betah 2 cholenic acid methyl ester 3 oxo 6beta,19 epoxy 4 cholenic acid methyl ester 3alpha hydroxy 2beta,19 epoxy 5alphah cholanic acid methyl ester 3alpha hydroxy 6beta,19 epoxy 4 cholenic acid 3alpha hydroxy 6beta,19 epoxy 4 cholenic acid methyl ester 3beta acetoxy 19 hydroxy 5 cholenic acid methyl ester 3beta acetoxy 5alpha bromo 6beta,19 epoxycholanic acid methyl ester 3beta hydroxy 19 acetoxy 5betah cholanic acid methyl ester 3beta,19 diacetoxy 5alphah cholanic acid methyl ester lithocholic acid liver X receptor liver X receptor alpha liver X receptor beta n,n dimethyl 3alpha hydroxy 2beta,19 epoxy 5betah cholanamide n,n dimethyl 3alpha hydroxy 5betah cholanamide n,n dimethyl 3alpha hydroxy 6beta,19 epoxy 4 cholenamide n,n dimethyl 3alpha,6alpha dihydroxy 5betah cholanamide n,n dimethyl 3beta hydroxy 2beta,19 epoxy 5alphah cholanamide n,n dimethyl 3beta hydroxy 5 cholenamide n,n dimethyl 3beta hydroxycholenamide steroid unclassified drug amide cholane derivative cholic acid derivative isoprotein N,N-dimethyl-3-hydroxy-5-cholenamide Article BHK-21 cell line cell culture chemical modification drug activity drug binding drug conformation drug screening drug structure drug synthesis genetic transfection human human cell hydrogen bond luciferase assay molecular dynamics agonists animal antagonists and inhibitors binding site cell line chemistry hamster metabolism protein tertiary structure synthesis Amides Animals Binding Sites Cell Line Cholanes Cholic Acids Cricetinae Humans Liver X Receptors Molecular Dynamics Simulation Protein Isoforms Protein Structure, Tertiary
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_09680896_v26_n5_p1092_Martinez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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