Synthesis and cholinesterase inhibition of cativic acid derivatives

Alzheimer's disease (AD) is a neurodegenerative disorder associated with memory impairment and cognitive deficit. Most of the drugs currently available for the treatment of AD are acetylcholinesterase (AChE) inhibitors. In a preliminary study, significant AChE inhibition was observed for the et...

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Detalles Bibliográficos
Autores principales: Alza, N.P., Richmond, V., Baier, C.J., Freire, E., Baggio, R., Murray, A.P.
Formato: JOUR
Materias:
Alzheimer's disease
Cholinesterase inhibitors
Diterpenoids
Labdane
Molecular modeling
SH-SY5Y neuroblastoma cells
1,2 dibromoethane
1,3 dibromopropane
1,4 dibromobutane
1,5 dibromopentane
1,6 dibromohexane
17 hydroxycativic acid
cativic acid derivative
cholinesterase
diethylamine
diterpenoid
morpholine
piperidine
plant extract
pyrrolidine
tertiary amine
unclassified drug
17-hydroxycativic acid
acetylcholinesterase
cholinesterase inhibitor
diterpene
article
catalysis
controlled study
drug structure
drug synthesis
enzyme active site
enzyme inhibition
enzyme kinetics
Grindelia
Grindelia ventanensis
human
human cell
IC 50
in vitro study
molecular docking
neuroblastoma cell
nonhuman
structure activity relation
toxicity testing
animal
binding site
chemistry
conformation
kinetics
metabolism
synthesis
tumor cell line
X ray crystallography
Acetylcholinesterase
Animals
Binding Sites
Butyrylcholinesterase
Catalytic Domain
Cell Line, Tumor
Cholinesterase Inhibitors
Crystallography, X-Ray
Diterpenes
Humans
Kinetics
Molecular Conformation
Molecular Docking Simulation
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09680896_v22_n15_p3838_Alza
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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