Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum

Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleo...

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Autores principales:	Gompel, M., Leost, M., Bal De Kier Joffe, E., Puricelli, L., Hernandez Franco, L., Palermo, J., Meijer, L.
Formato:	JOUR
Materias:	Cancer CDK Cyclin-dependent kinase Glycogen synthase kinase Glycogen synthase kinase-3 GSK-3 Kinase inhibitor MEM Meridianin Modified Eagle Medium MTT Neurodegenerative diseases Protein kinase casein kinase I cyclic nucleotide dependent protein kinase cyclin dependent kinase discodermindol glycogen synthase kinase 3 isomeridianin c isomeridianin g meridianin meridianin a meridianin b meridianin c meridianin d meridianin e meridianin f meridianin g protein kinase inhibitor psammopemmin a psammopemmin b psammopemmin c unclassified drug variolin b Aplidium meridianum apoptosis article Ascidiacea cell death cell division cell proliferation controlled study drug mechanism enzyme activity enzyme inhibition human human cell nonhuman pharmacodynamics Aminopyridines Animals Cell Division Cell Line, Tumor Cell Survival Dose-Response Relationship, Drug Enzyme Inhibitors Humans Indole Alkaloids Mice Protein Kinase Inhibitors Urochordata Aplidium Ascidia Ciconiiformes
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_0960894X_v14_n7_p1703_Gompel
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	todo:paper_0960894X_v14_n7_p1703_Gompel2023-10-03T15:53:59Z Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum Gompel, M. Leost, M. Bal De Kier Joffe, E. Puricelli, L. Hernandez Franco, L. Palermo, J. Meijer, L. Cancer CDK Cyclin-dependent kinase Glycogen synthase kinase Glycogen synthase kinase-3 GSK-3 Kinase inhibitor MEM Meridianin Modified Eagle Medium MTT Neurodegenerative diseases Protein kinase casein kinase I cyclic nucleotide dependent protein kinase cyclin dependent kinase discodermindol glycogen synthase kinase 3 isomeridianin c isomeridianin g meridianin meridianin a meridianin b meridianin c meridianin d meridianin e meridianin f meridianin g protein kinase inhibitor psammopemmin a psammopemmin b psammopemmin c unclassified drug variolin b Aplidium meridianum apoptosis article Ascidiacea cell death cell division cell proliferation controlled study drug mechanism enzyme activity enzyme inhibition human human cell nonhuman pharmacodynamics Aminopyridines Animals Cell Division Cell Line, Tumor Cell Survival Dose-Response Relationship, Drug Enzyme Inhibitors Humans Indole Alkaloids Mice Protein Kinase Inhibitors Urochordata Aplidium Aplidium meridianum Ascidia Ciconiiformes Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases and casein kinase 1. Meridianins prevent cell proliferation and induce apoptosis, a demonstration of their ability to enter cells and to interfere with the activity of kinases important for cell division and cell death. These results suggest that meridianins constitute a promising scaffold from which more potent and selective protein kinase inhibitors could be designed. © 2004 Elsevier Ltd. All rights reserved. Fil:Puricelli, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Palermo, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0960894X_v14_n7_p1703_Gompel
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Cancer CDK Cyclin-dependent kinase Glycogen synthase kinase Glycogen synthase kinase-3 GSK-3 Kinase inhibitor MEM Meridianin Modified Eagle Medium MTT Neurodegenerative diseases Protein kinase casein kinase I cyclic nucleotide dependent protein kinase cyclin dependent kinase discodermindol glycogen synthase kinase 3 isomeridianin c isomeridianin g meridianin meridianin a meridianin b meridianin c meridianin d meridianin e meridianin f meridianin g protein kinase inhibitor psammopemmin a psammopemmin b psammopemmin c unclassified drug variolin b Aplidium meridianum apoptosis article Ascidiacea cell death cell division cell proliferation controlled study drug mechanism enzyme activity enzyme inhibition human human cell nonhuman pharmacodynamics Aminopyridines Animals Cell Division Cell Line, Tumor Cell Survival Dose-Response Relationship, Drug Enzyme Inhibitors Humans Indole Alkaloids Mice Protein Kinase Inhibitors Urochordata Aplidium Aplidium meridianum Ascidia Ciconiiformes
spellingShingle	Cancer CDK Cyclin-dependent kinase Glycogen synthase kinase Glycogen synthase kinase-3 GSK-3 Kinase inhibitor MEM Meridianin Modified Eagle Medium MTT Neurodegenerative diseases Protein kinase casein kinase I cyclic nucleotide dependent protein kinase cyclin dependent kinase discodermindol glycogen synthase kinase 3 isomeridianin c isomeridianin g meridianin meridianin a meridianin b meridianin c meridianin d meridianin e meridianin f meridianin g protein kinase inhibitor psammopemmin a psammopemmin b psammopemmin c unclassified drug variolin b Aplidium meridianum apoptosis article Ascidiacea cell death cell division cell proliferation controlled study drug mechanism enzyme activity enzyme inhibition human human cell nonhuman pharmacodynamics Aminopyridines Animals Cell Division Cell Line, Tumor Cell Survival Dose-Response Relationship, Drug Enzyme Inhibitors Humans Indole Alkaloids Mice Protein Kinase Inhibitors Urochordata Aplidium Aplidium meridianum Ascidia Ciconiiformes Gompel, M. Leost, M. Bal De Kier Joffe, E. Puricelli, L. Hernandez Franco, L. Palermo, J. Meijer, L. Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
topic_facet	Cancer CDK Cyclin-dependent kinase Glycogen synthase kinase Glycogen synthase kinase-3 GSK-3 Kinase inhibitor MEM Meridianin Modified Eagle Medium MTT Neurodegenerative diseases Protein kinase casein kinase I cyclic nucleotide dependent protein kinase cyclin dependent kinase discodermindol glycogen synthase kinase 3 isomeridianin c isomeridianin g meridianin meridianin a meridianin b meridianin c meridianin d meridianin e meridianin f meridianin g protein kinase inhibitor psammopemmin a psammopemmin b psammopemmin c unclassified drug variolin b Aplidium meridianum apoptosis article Ascidiacea cell death cell division cell proliferation controlled study drug mechanism enzyme activity enzyme inhibition human human cell nonhuman pharmacodynamics Aminopyridines Animals Cell Division Cell Line, Tumor Cell Survival Dose-Response Relationship, Drug Enzyme Inhibitors Humans Indole Alkaloids Mice Protein Kinase Inhibitors Urochordata Aplidium Aplidium meridianum Ascidia Ciconiiformes
description	Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases such as cyclin-dependent kinases, glycogen synthase kinase-3, cyclic nucleotide-dependent kinases and casein kinase 1. Meridianins prevent cell proliferation and induce apoptosis, a demonstration of their ability to enter cells and to interfere with the activity of kinases important for cell division and cell death. These results suggest that meridianins constitute a promising scaffold from which more potent and selective protein kinase inhibitors could be designed. © 2004 Elsevier Ltd. All rights reserved.
format	JOUR
author	Gompel, M. Leost, M. Bal De Kier Joffe, E. Puricelli, L. Hernandez Franco, L. Palermo, J. Meijer, L.
author_facet	Gompel, M. Leost, M. Bal De Kier Joffe, E. Puricelli, L. Hernandez Franco, L. Palermo, J. Meijer, L.
author_sort	Gompel, M.
title	Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
title_short	Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
title_full	Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
title_fullStr	Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
title_full_unstemmed	Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
title_sort	meridianins, a new family of protein kinase inhibitors isolated from the ascidian aplidium meridianum
url	http://hdl.handle.net/20.500.12110/paper_0960894X_v14_n7_p1703_Gompel
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Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum

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