Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone
3α-Hydroxy-6,19-oxidopregn-4-ene-20-one (4) was prepared in seven steps from pregnanolone acetate. At 0.1 μM concentration 4 significantly increased GABA induced 36Cl- influx in hamster cerebral cortex synaptoneurosomes while at 20 mg/kg it decreased the percentage of hamsters showing seizures induc...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0960894X_v13_n3_p343_Veleiro |
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todo:paper_0960894X_v13_n3_p343_Veleiro2023-10-03T15:53:58Z Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone Veleiro, A.S. Rosenstein, R.E. Jaliffa, C.O. Grilli, M.L. Speroni, F. Burton, G. 3 mercaptopropionic acid 3alpha hydroxy 6,19 oxidopregn 4 en 20 one 4 aminobutyric acid A receptor acetic acid derivative anticonvulsive agent chloride ion eltanolone unclassified drug animal cell animal experiment article brain cortex brain synaptosome chloride transport concentration response controlled study dose response drug activity drug synthesis hamster nonhuman seizure 3-Mercaptopropionic Acid Animals Cerebral Cortex Convulsants Cricetinae Indicators and Reagents Pregnanolone Receptors, GABA-A Seizures Stereoisomerism Structure-Activity Relationship Synaptosomes Cricetinae 3α-Hydroxy-6,19-oxidopregn-4-ene-20-one (4) was prepared in seven steps from pregnanolone acetate. At 0.1 μM concentration 4 significantly increased GABA induced 36Cl- influx in hamster cerebral cortex synaptoneurosomes while at 20 mg/kg it decreased the percentage of hamsters showing seizures induced by 3-mercaptopropionic acid. © 2002 Elsevier Science Ltd. All rights reserved. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_0960894X_v13_n3_p343_Veleiro |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
3 mercaptopropionic acid 3alpha hydroxy 6,19 oxidopregn 4 en 20 one 4 aminobutyric acid A receptor acetic acid derivative anticonvulsive agent chloride ion eltanolone unclassified drug animal cell animal experiment article brain cortex brain synaptosome chloride transport concentration response controlled study dose response drug activity drug synthesis hamster nonhuman seizure 3-Mercaptopropionic Acid Animals Cerebral Cortex Convulsants Cricetinae Indicators and Reagents Pregnanolone Receptors, GABA-A Seizures Stereoisomerism Structure-Activity Relationship Synaptosomes Cricetinae |
| spellingShingle |
3 mercaptopropionic acid 3alpha hydroxy 6,19 oxidopregn 4 en 20 one 4 aminobutyric acid A receptor acetic acid derivative anticonvulsive agent chloride ion eltanolone unclassified drug animal cell animal experiment article brain cortex brain synaptosome chloride transport concentration response controlled study dose response drug activity drug synthesis hamster nonhuman seizure 3-Mercaptopropionic Acid Animals Cerebral Cortex Convulsants Cricetinae Indicators and Reagents Pregnanolone Receptors, GABA-A Seizures Stereoisomerism Structure-Activity Relationship Synaptosomes Cricetinae Veleiro, A.S. Rosenstein, R.E. Jaliffa, C.O. Grilli, M.L. Speroni, F. Burton, G. Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone |
| topic_facet |
3 mercaptopropionic acid 3alpha hydroxy 6,19 oxidopregn 4 en 20 one 4 aminobutyric acid A receptor acetic acid derivative anticonvulsive agent chloride ion eltanolone unclassified drug animal cell animal experiment article brain cortex brain synaptosome chloride transport concentration response controlled study dose response drug activity drug synthesis hamster nonhuman seizure 3-Mercaptopropionic Acid Animals Cerebral Cortex Convulsants Cricetinae Indicators and Reagents Pregnanolone Receptors, GABA-A Seizures Stereoisomerism Structure-Activity Relationship Synaptosomes Cricetinae |
| description |
3α-Hydroxy-6,19-oxidopregn-4-ene-20-one (4) was prepared in seven steps from pregnanolone acetate. At 0.1 μM concentration 4 significantly increased GABA induced 36Cl- influx in hamster cerebral cortex synaptoneurosomes while at 20 mg/kg it decreased the percentage of hamsters showing seizures induced by 3-mercaptopropionic acid. © 2002 Elsevier Science Ltd. All rights reserved. |
| format |
JOUR |
| author |
Veleiro, A.S. Rosenstein, R.E. Jaliffa, C.O. Grilli, M.L. Speroni, F. Burton, G. |
| author_facet |
Veleiro, A.S. Rosenstein, R.E. Jaliffa, C.O. Grilli, M.L. Speroni, F. Burton, G. |
| author_sort |
Veleiro, A.S. |
| title |
Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone |
| title_short |
Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone |
| title_full |
Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone |
| title_fullStr |
Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone |
| title_full_unstemmed |
Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone |
| title_sort |
synthesis and gabaa receptor activity of a 6,19-oxido analogue of pregnanolone |
| url |
http://hdl.handle.net/20.500.12110/paper_0960894X_v13_n3_p343_Veleiro |
| work_keys_str_mv |
AT veleiroas synthesisandgabaareceptoractivityofa619oxidoanalogueofpregnanolone AT rosensteinre synthesisandgabaareceptoractivityofa619oxidoanalogueofpregnanolone AT jaliffaco synthesisandgabaareceptoractivityofa619oxidoanalogueofpregnanolone AT grilliml synthesisandgabaareceptoractivityofa619oxidoanalogueofpregnanolone AT speronif synthesisandgabaareceptoractivityofa619oxidoanalogueofpregnanolone AT burtong synthesisandgabaareceptoractivityofa619oxidoanalogueofpregnanolone |
| _version_ |
1807314964491272192 |