Endothelin-1 stimulation of aldosterone and zona glomerulosa ouabain-sensitive sodium/potassium-ATPase

Endothelin stimulates the cells of the zona glomerulosa of the adrenal gland and releases aldosterone. While it is a less potent aldosterone secretagogue than angiotensin II endothelin also potentiates the effects of angiotensin II on aldosterone biosynthesis. Two endothelin receptors have been clon...

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Detalles Bibliográficos
Autores principales: Pecci, A., Cozza, E.N., Devlin, M., Gomez-Sanchez, C.E., Gomez-Sanchez, E.P.
Formato: JOUR
Materias:
adenosine triphosphatase (potassium sodium)
aldosterone
cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl)
endothelin 1
endothelin receptor
endothelin receptor antagonist
ouabain
sarafotoxin
aldosterone release
animal cell
animal experiment
article
blood pressure
controlled study
gene expression
molecular cloning
nonhuman
rat
zona glomerulosa
Aldosterone
Animal
Aorta
Blood Pressure
Cloning, Molecular
Endothelins
Na(+)-K(+)-Exchanging ATPase
Ouabain
Rats
Rats, Inbred Strains
Rats, Sprague-Dawley
Receptors, Endothelin
Support, Non-U.S. Gov't
Support, U.S. Gov't, Non-P.H.S.
Support, U.S. Gov't, P.H.S.
Zona Glomerulosa
Animalia
Strophanthus gratus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09600760_v50_n1-2_p49_Pecci
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Endothelin stimulates the cells of the zona glomerulosa of the adrenal gland and releases aldosterone. While it is a less potent aldosterone secretagogue than angiotensin II endothelin also potentiates the effects of angiotensin II on aldosterone biosynthesis. Two endothelin receptors have been cloned and are expressed in the adrenal zona glomerulosa. Intravenous infusion of endothelin at a rate of 80 ng/kg/min for 30 min into rats produced increases in blood pressure, adrenal content of aldosterone and stimulated the ouabain-sensitive sodium potassium ATPase in the zona glomerulosa, but not in the zona fasciculata, of the adrenal. The simultaneous infusion of the isopeptide specific endothelin receptor A (ETA) antagonist BQ-123 blocked the pressor effects of endothelin, but did not alter the increase in aldosterone content of the zona glomerulosa or the ouabain-sensitive sodium potassium ATPase activity. Infusion of Sarafotoxin 6b, an ETB agonist, also increased the aldosterone content of the adrenal and stimulated the ouabain-sensitive sodium potassium ATPase in the zona glomerulosa, further indicating that the effect of endothelin is probably mediated by ETB or isopeptide non-specific endothelin receptor. The mechanism by which endothelin stimulates the sodium potassium ATPase is unclear as is the relation between a stimulated sodium potassium ATPase and the potentiation of angiotensin II effect on the adrenal. © 1994.

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