Fluorinated oxysterol analogues: Synthesis, molecular modelling and LXRβ activity

Liver X receptors (LXRs) are nuclear receptors that play central roles in the transcriptional control of lipid metabolism. The ability of LXRs to integrate metabolic and inflammation signalling makes them attractive targets for intervention in human metabolic diseases. Several oxidized metabolites o...

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Detalles Bibliográficos
Autores principales: Rodriguez, C.R., Alvarez, L.D., Dansey, M.V., Paolo, L.S., Veleiro, A.S., Pecci, A., Burton, G.
Formato: JOUR
Materias:
Cholestenoic acid
Liver X receptor
Molecular dynamics
Oxysterols
25,25 difluoro 27 norcholest 5 ene 3beta,26 diol
25,25 difluoro 27 norcholestenoic acid
25,25 difluoroacid
27 norcholestenoic acid
alcohol derivative
aldehyde
ethyl bromodifluoroacetate
fluoroacetic acid
histidine
hydrogen
liver X receptor
liver X receptor beta
oxysterol
tryptophan
unclassified drug
25,25-difluoro-27-nor-26-hydroxycholesterol
25,25-difluoro-27-norcholestenoic acid
3 [3 [[2 chloro 3 (trifluoromethyl)benzyl](2 diphenylethyl)amino]propoxy]phenylacetic acid
benzoic acid derivative
benzylamine derivative
cholestane derivative
cholestenoic acid
cholesterol
cholesterol derivative
fluorine
ligand
norsteroid
protein binding
Article
conformational transition
deoxygenation
expression vector
fluorination
HEK293 cell line
human
human cell
hydrogen bond
irradiation
ligand binding
luciferase assay
molecular dynamics
molecular interaction
molecular model
Reformatsky reaction
synthesis
ultrasound
agonists
antagonists and inhibitors
chemistry
nuclear magnetic resonance spectroscopy
signal transduction
tissue distribution
Alcohols
Benzoates
Benzylamines
Cholestenes
Cholesterol
Fluorine
HEK293 Cells
Humans
Hydrogen Bonding
Hydroxycholesterols
Ligands
Liver X Receptors
Magnetic Resonance Spectroscopy
Molecular Dynamics Simulation
Norsteroids
Protein Binding
Signal Transduction
Tissue Distribution
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09600760_v165_n_p268_Rodriguez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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