In vitro secretion of cytokines and prostaglandin-E2 by monocytes from lung cancer patients

Monocytes (MO) from cancer patients present functional abnormalities, such as an altered secretion of soluble factors. In the present study, our aim was to evaluate the levels of interleukin-1β (IL-1β), tumour necrosis factor-alpha (TNF-α) and prostaglandin-E2 (PGE2) secreted in vitro by MO from lun...

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Detalles Bibliográficos
Autores principales: Trejo, Y.G., Bordenave, R.H., Beviacqua, M., Rumi, L.S.
Formato: JOUR
Materias:
Il-1β
Lung cancer
Monocytes
Pge2
Tna-α
cytokine
interleukin 1beta
lipopolysaccharide
prostaglandin E2
tumor necrosis factor alpha
article
cell secretion
cell stimulation
clinical article
controlled study
cytokine release
human
human cell
in vitro study
lung cancer
monocyte
priority journal
prostaglandin release
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_09546111_v95_n4_p243_Trejo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Monocytes (MO) from cancer patients present functional abnormalities, such as an altered secretion of soluble factors. In the present study, our aim was to evaluate the levels of interleukin-1β (IL-1β), tumour necrosis factor-alpha (TNF-α) and prostaglandin-E2 (PGE2) secreted in vitro by MO from lung cancer patients (LCP), spontaneously or after stimulation with lipopolysaccharide (LPS). Results showed that cytokine secretion was higher for MO from LCP than for MO from healthy controls, while in the 25% of the patients analysed, an absence of response to LPS treatment was found. © 2001 Harcourt Publishers Ltd.

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