The immunoregulatory glycan-binding protein galectin-1 triggers human platelet activation

Platelet activation is a critical process during inflammation, thrombosis, and cancer. Here, we show that galectin-1, an endogenous lectin with immunoregulatory properties, plays a key role in human platelet activation and function. Galectin-1 binds to human platelets in a carbohydrate-dependent man...

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Detalles Bibliográficos
Autores principales: Pacienza, N., Pozner, R.G., Bianco, G.A., D'Atri, L.P., Croci, D.O., Negrotto, S., Malaver, E., Gómez, R.M., Rabinovich, G.A., Schattner, M.
Formato: JOUR
Materias:
Hemostasis
Inflammation
Lectin
P-selectin
adenosine diphosphate
adenosine triphosphate
calcium ion
carbohydrate binding protein
cyclic nucleotide
F actin
galectin 1
glycan
glycoprotein IIIa
PADGEM protein
thrombin
article
cell interaction
controlled study
human
human cell
immunoregulation
leukocyte
normal human
polymerization
priority journal
protein binding
protein induction
thrombocyte activation
thrombocyte aggregation
thrombocyte function
thrombocyte release reaction
upregulation
Actins
Adenosine Diphosphate
Binding Sites
Blood Platelets
Flow Cytometry
Galectin 1
Humans
Integrin beta3
Leukocytes
Microscopy, Confocal
P-Selectin
Platelet Activation
Platelet Aggregation
Signal Transduction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_08926638_v22_n4_p1113_Pacienza
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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