The Caenorhabditis elegans DAF-12 nuclear receptor: Structure, dynamics, and interaction with ligands

A structure for the ligand binding domain (LBD) of the DAF-12 receptor from Caenorhabditis elegans was obtained from the X-ray crystal structure of the receptor LBD from Strongyloides stercoralis bound to (25R)-Δ7-dafachronic acid (DA) (pdb:3GYU). The model was constructed in the presence of the lig...

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Detalles Bibliográficos
Autores principales: Alvarez, L.D., Mañez, P.A., Estrin, D.A., Burton, G.
Formato: JOUR
Materias:
C. elegans
Dafachronic acid
Molecular dynamics
Nuclear receptor, DAF-12
arginine
Caenorhabditis elegans protein
carboxylic acid
cell nucleus receptor
DAF 12 nuclear receptor
unclassified drug
article
binding site
Caenorhabditis elegans
crystal structure
gene mutation
molecular docking
molecular dynamics
molecular model
nonhuman
priority journal
protein analysis
protein interaction
protein structure
Strongyloides stercoralis
transactivation
X ray crystallography
Amino Acid Sequence
Animals
Arginine
Binding Sites
Caenorhabditis elegans Proteins
Cholestenes
Ligands
Molecular Dynamics Simulation
Molecular Sequence Data
Protein Binding
Receptors, Cytoplasmic and Nuclear
Sequence Alignment
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_08873585_v80_n7_p1798_Alvarez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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