Engineering of a polymeric bacterial protein as a scaffold for the multiple display of peptides

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Protein assemblies with a high degree of repetitiveness and organization are known to induce strong immune responses. For that reason they have been postulated for the design of subunit vaccines by means of protein engineering. The enzyme lumazine synthase from Brucella spp. (BLS) is highly immunoge...

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Detalles Bibliográficos
Autores principales: Laplagne, D.A., Zylberman, V., Ainciart, N., Steward, M.W., Sciutto, E., Fossati, C.A., Goldbaum, F.A.
Formato: JOUR
Materias:
Chimeric protein
Decamer
Immunogenicity
Multiple display of peptides
Polyvalent chimeras
Stability
bacterial enzyme
bacterial protein
chimeric protein
lumazine synthase
peptide
subunit vaccine
unclassified drug
article
Brucella
chimera
immune response
immune system
nonhuman
polymerization
priority journal
protein assembly
protein engineering
protein folding
protein stability
stoichiometry
structure analysis
thermodynamics
Amino Acid Sequence
Animals
Bacterial Proteins
Biopolymers
Circular Dichroism
Gene Expression
Genetic Vectors
Mice
Mice, Inbred BALB C
Models, Molecular
Molecular Sequence Data
Multienzyme Complexes
Peptide Library
Protein Engineering
Protein Folding
Recombinant Fusion Proteins
Bacteria (microorganisms)
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_08873585_v57_n4_p820_Laplagne
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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