SF2/ASF regulates proteomic diversity by affecting the balance between translation initiation mechanisms

Post-splicing activities have been described for a subset of shuttling serine/arginine-rich splicing regulatory proteins, among them SF2/ASF. We showed that growth factors activate a Ras-PI 3-kinase-Akt/PKB signaling pathway that not only modifies alternative splicing of the fibronectin EDA exon, bu...

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Detalles Bibliográficos
Autores principales: Blaustein, M., Quadrana, L., Risso, G., De La Mata, M., Pelisch, F., Srebrow, A.
Formato: JOUR
Materias:
Alternative splicing
Cap-dependent translation
FGF-2
IRES-dependent translation
SF2/ASF
SR proteins
arginine
ectodysplasin A
fibroblast growth factor 2
fibronectin
messenger RNA
phosphatidylinositol 3 kinase
protein asf
protein kinase B
protein sf2
Ras protein
serine
unclassified drug
article
human
human cell
in vivo study
internal ribosome entry site
priority journal
protein expression
protein function
protein motif
proteomics
translation initiation
Eukaryota
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_07302312_v107_n4_p826_Blaustein
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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