Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice

CaV2.1 Ca2+ channels play a key role in triggering neurotransmitter release and mediating synaptic transmission. Familial hemiplegic migraine type-1 (FHM-1) is caused by missense mutations in the CACNA1A gene that encodes the α1A pore-forming subunit of CaV2.1 Ca2+ channels. We used knock-in (KI) tr...

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Detalles Bibliográficos
Autores principales:	Inchauspe, C.G., Pilati, N., Di Guilmi, M.N., Urbano, F.J., Ferrari, M.D., van den Maagdenberg, A.M.J.M., Forsythe, I.D., Uchitel, O.D.
Formato:	JOUR
Materias:	arginine calcium channel calcium channel CaV2.1 glutamine unclassified drug agents interacting with transmitter, hormone or drug receptors calcium channel N type codon glycine voltage-dependent calcium channel (P-Q type) animal cell animal experiment Article auditory nervous system brain stem controlled study evoked response excitatory synaptic transmission familial hemiplegic migraine familial hemiplegic migraine type 1 inhibitory synaptic transmission lateral superior olive missense mutation mouse mutational analysis nerve cell nerve cell plasticity nerve excitability nerve stimulation nervous system parameters neurotransmission nonhuman pathophysiology postsynaptic potential protein function sensory nerve short term depression superior olivary nucleus synaptic transmission transgenic mouse animal cerebellar ataxia chemistry electrophysiology exon genetics metabolism migraine mutation probability Animals Brain Stem Calcium Channels, N-Type Cerebellar Ataxia Codon Electrophysiology Exons Glutamine Glycine Mice Mice, Transgenic Migraine Disorders Mutation Neuronal Plasticity Neurons Neurotransmitter Agents Probability Superior Olivary Complex Synaptic Transmission
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_03785955_v319_n_p56_Inchauspe
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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