Synthesis of |21‐14C|‐3β‐hydroxy‐5β‐pregnan‐20‐one and |21‐14C|‐5β‐cholestan‐3β‐ol

|21‐14C|‐3β‐Hydroxy‐5β‐pregnan‐20‐one was synthesised from 3β‐acetoxy‐5β‐androstan‐17β‐carboxylic acid chloride and |14C2|dimethyl‐cadmium. Reaction of the labelled product with isohexyl bromide yielded, after dehydration and catalytic hydrogenation, |21‐14C|‐5β‐cholestan‐3β‐ol (|21‐14C|‐coprostanol...

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Detalles Bibliográficos
Autores principales: Garraffo, H.M., Deluca, M.E., Seldes, A.M., Gross, E.G.
Formato: JOUR
Materias:
Synthesis
|21‐14C|‐3β‐Hydroxy‐5β‐pregnan‐20‐one
|21‐14C|‐Coprostanol
radioisotope
5beta pregnan 3beta ol 20 one c 14
coprosterol c 14
drug analysis
drug identification
drug synthesis
mass spectrometry
nonhuman
nuclear magnetic resonance
priority journal
proton nuclear magnetic resonance
theoretical study
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03624803_v22_n7_p673_Garraffo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:|21‐14C|‐3β‐Hydroxy‐5β‐pregnan‐20‐one was synthesised from 3β‐acetoxy‐5β‐androstan‐17β‐carboxylic acid chloride and |14C2|dimethyl‐cadmium. Reaction of the labelled product with isohexyl bromide yielded, after dehydration and catalytic hydrogenation, |21‐14C|‐5β‐cholestan‐3β‐ol (|21‐14C|‐coprostanol). Copyright © 1985 John Wiley & Sons, Ltd.

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