Progesterone down-regulates spinal cord inflammatory mediators and increases myelination in experimental autoimmune encephalomyelitis

In mice with experimental autoimmune encephalomyelitis (EAE) pretreatment with progesterone improves clinical signs and decreases the loss of myelin basic protein (MBP) and proteolipid protein (PLP) measured by immunohistochemistry and in situ hybridization. Presently, we analyzed if progesterone ef...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Garay, L.I., González Deniselle, M.C., Brocca, M.E., Lima, A., Roig, P., De Nicola, A.F.
Formato: JOUR
Materias:
Experimental autoimmune encephalomyelitis
Myelin proteins
Neuroprotection
Progesterone
Proinflammatory mediators
Transcription factors
autacoid
CD11b antigen
glial fibrillary acidic protein
messenger RNA
myelin basic protein
progesterone
protein Olig1
proteolipid protein
toll like receptor 4
transcription factor
transcription factor Nkx2.2
tumor necrosis factor alpha
tumor necrosis factor receptor 1
unclassified drug
allergic encephalomyelitis
animal cell
animal experiment
animal model
animal tissue
article
astrocyte
confocal microscopy
controlled study
down regulation
drug mechanism
female
immunocytochemistry
immunohistochemistry
in situ hybridization
microglia
mouse
myelination
nonhuman
nucleotide sequence
oligodendroglia
pharmacological blocking
priority journal
protein localization
real time polymerase chain reaction
spinal cord
Animals
Calcium-Binding Proteins
Down-Regulation
Encephalomyelitis, Autoimmune, Experimental
Female
Immunohistochemistry
Inflammation Mediators
Mice
Mice, Inbred C57BL
Microfilament Proteins
Microglia
Microscopy, Confocal
Myelin Proteins
Myelin Sheath
Oligodendroglia
Real-Time Polymerase Chain Reaction
RNA, Messenger
Spinal Cord
Transcription Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03064522_v226_n_p40_Garay
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares