Long-term memory consolidation depends on proteasome activity in the crab Chasmagnathus
Long-term memory formation depends on protein and mRNA synthesis that subserves synaptic reorganization. The removal of pre-existing inhibitory proteins by the ubiquitin-proteasome system (UPS) is proposed as a crucial step to support these modifications. The activation of the constitutive transcrip...
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| Autores principales: | , |
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_03064522_v147_n1_p46_Merlo |
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| Sumario: | Long-term memory formation depends on protein and mRNA synthesis that subserves synaptic reorganization. The removal of pre-existing inhibitory proteins by the ubiquitin-proteasome system (UPS) is proposed as a crucial step to support these modifications. The activation of the constitutive transcription factor nuclear factor κB (NF-κB) depends on the degradation of the inhibitor of NF-κB (IκB) by the UPS. Here we study the effect of a UPS inhibitor, MG132, on long-term memory consolidation and NF-κB activation in the learning paradigm of the crab Chasmagnathus, a model in which this transcription factor plays a key role. Here we found that administration of MG132 interferes with long-term memory but not with short-term memory, and no facilitatory effects were found. Then we studied the effect of the UPS inhibitor on NF-κB pathway, finding that MG132 blocks the activation of NF-κB induced by training. These results suggest that the UPS is necessary for long-term memory consolidation, allowing for the activation of NF-κB as one of the target molecular pathways. © 2007 IBRO. |
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