Reducing sugars trigger δ-aminolevulinic dehydratase inactivation evidence of in vitro aspirin prevention

The effect of in vitro glycation on δ-aminolevulinic dehydratase (ALA-D) under several experimental conditions was investigated. When preincubated with 500 mM glucose at 37°C for 20 hr, ALA-D was 80% inactivated and glycated hemoglobin levels were increased more than fourfold.Thiobarbituric acid spe...

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Detalles Bibliográficos
Autores principales: Caballero, F.A., Gerez, E.N., Polo, C.F., Vazquez, E.S., Del C. Batlle, A.M.
Formato: JOUR
Materias:
δ-aminolevulinic dehydratase
Acetyl salicylic acid
Carbohydrates
Enzyme inactivation
Glycated hemoglobin
Glycation
Lipid peroxidation
acetylsalicylic acid
carbohydrate
glycosylated hemoglobin
porphobilinogen synthase
thiobarbituric acid
article
enzyme activity
enzyme inactivation
erythrocyte
human
human cell
lipid peroxidation
priority journal
protein glycosylation
temperature
Aspirin
Carbohydrate Metabolism
Glucose
Glycosylation
Hemoglobin A, Glycosylated
Humans
Lipid Peroxidation
Porphobilinogen Synthase
Temperature
Time Factors
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03063623_v31_n3_p441_Caballero
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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