Trypanosoma cruzi as a model system to study the expression of exogenous genes coding for polyamine biosynthetic enzymes. Induction of DFMO resistance in transgenic parasites

Trypanosoma cruzi, the etiologic agent of Chagas' disease, is a polyamine auxotroph organism because its genome contains neither ornithine decarboxylase (ODC) nor arginine decarboxylase (ADC) genes, presumably lost during evolution. After transformation with a recombinant plasmid bearing the co...

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Detalles Bibliográficos
Autores principales: Carrillo, C., González, N.S., Algranati, I.D.
Formato: JOUR
Materias:
DFMO resistance
Ornithine decarboxylase
Polyamine biosynthesis
Transgenic parasites
Trypanosoma cruzi
eflornithine
messenger RNA
ornithine decarboxylase
polyamine
article
controlled study
enzyme activity
gene amplification
gene duplication
gene expression
genetic transcription
nonhuman
priority journal
RNA translation
transgenic organism
Animals
Animals, Genetically Modified
Base Sequence
Biogenic Polyamines
Blotting, Northern
Blotting, Southern
DNA Primers
Eflornithine
Gene Expression
Ornithine Decarboxylase
Polymerase Chain Reaction
Crithidia fasciculata
Protozoa
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03044165_v1770_n12_p1605_Carrillo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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