Synergistic effect of mammary tumors on hexachlorobenzene-induced porphyria in rats

The response of animals bearing N-nitroso-N-methylurea (NMU)-induced mammary tumors to the porphyrinogenic action of hexachlorobenzene (HCB) was studied. δ-Aminolevulinic acid (ALA), porphobilinogen and porphyrins in urine, ALA-synthase and porphyrinogen carboxylyase activities and porphyrin content...

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Detalles Bibliográficos
Autores principales: Wainstok de Calmanovici, R., Cochón, A.C., Aldonatti, C., Bergoc, R., San Martín de Viala, L.C.
Formato: JOUR
Materias:
heme pathway
hexachlorobenzene
mammary tumor
N-nitroso-N-methylurea
porphyrins
porphyris
methylnitrosourea
animal experiment
article
breast
breast tumor
controlled study
female
nonhuman
porphyria
priority journal
rat
5-Aminolevulinate Synthetase
Animal
Female
Hexachlorobenzene
Mammary Neoplasms, Experimental
Porphyria
Porphyrins
Rats
Rats, Inbred Strains
Support, Non-U.S. Gov't
Animalia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03043835_v55_n1_p67_WainstokdeCalmanovici
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:The response of animals bearing N-nitroso-N-methylurea (NMU)-induced mammary tumors to the porphyrinogenic action of hexachlorobenzene (HCB) was studied. δ-Aminolevulinic acid (ALA), porphobilinogen and porphyrins in urine, ALA-synthase and porphyrinogen carboxylyase activities and porphyrin content in liver and tumor were measured. The results obtained indicate that the metabolic heme pathway operates in mammary tumors but tumor response to HCB treatment could not be detected. HCB administration produced an earlier and greater hepatic porphyria in tumor-bearing rats than in healthy rats suggesting that the presence of tumors exacerbates the action of HCB. © 1990.

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