Nuclear translocation of p19INK4d in response to oxidative DNA damage promotes chromatin relaxation

DNA is continuously exposed to damaging agents that can lead to changes in the genetic information with adverse consequences. Nonetheless, eukaryotic cells have mechanisms such as the DNA damage response (DDR) to prevent genomic instability. The DNA of eukaryotic cells is packaged into nucleosomes,...

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Detalles Bibliográficos
Autores principales: Sonzogni, S.V., Ogara, M.F., Castillo, D.S., Sirkin, P.F., Radicella, J.P., Cánepa, E.T.
Formato: JOUR
Materias:
Chromatin relaxation
DNA damage response
Genome integrity
p19INK4d
cyclin dependent kinase inhibitor 2D
nuclear protein
restriction endonuclease
chromatin
green fluorescent protein
protein binding
animal cell
Article
cell nucleus
cell survival
chromatin structure
controlled study
DNA damage
DNA repair
genetic stability
genomic instability
human
human cell
intracellular transport
nonhuman
oxidative stress
protein DNA binding
protein DNA interaction
protein function
protein transport
active transport
animal
cell line
confocal microscopy
genetics
HEK293 cell line
HeLa cell line
metabolism
Northern blotting
Western blotting
Eukaryota
Active Transport, Cell Nucleus
Animals
Blotting, Northern
Blotting, Western
Cell Line
Cell Nucleus
Chromatin
Cyclin-Dependent Kinase Inhibitor p19
DNA Damage
DNA Repair
Green Fluorescent Proteins
HEK293 Cells
HeLa Cells
Humans
Microscopy, Confocal
Oxidative Stress
Protein Binding
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03008177_v398_n1-2_p63_Sonzogni
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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