ACTH stimulates the release of alkaline phosphatase through Gi-mediated activation of a phospholipase C and the release of inositolphosphoglycan

We have previously reported that ACTH activates a phospholipase C that hydrolyzes glycosylphosphatidylinositol (GPI), which would release inositolphosphoglycan (IPG) to the extracellular medium, and that an IPG purified from Trypanosoma cruzi is able to inhibit ACTH-mediated steroid production in ad...

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Detalles Bibliográficos
Autores principales: Martini, C.N., Vaena de Avalos, S.G., del Carmen Vila, M.
Formato: JOUR
Materias:
ACTH
Alkaline phosphate
Gi
Glycosylphosphatidylinositol (GPI)
Phospholipase C
Steroid biosynthesis
1 [[6 (3 methoxyestra 1,3,5(10) trien 17beta yl)amino]hexyl] 1h pyrrole 2,5 dione
alkaline phosphatase
antibody
bucladesine
corticosterone
corticotropin
cyclic AMP
glycan derivative
glycosylphosphatidylinositol
guanine nucleotide binding protein
inhibitory guanine nucleotide binding protein
inositol phosphate
pertussis toxin
phospholipase C
phospholipase C inhibitor
sodium chloride
triton x 114
adrenal cortex cell
animal cell
article
cell culture
controlled study
culture medium
enzyme activation
enzyme release
extracellular fluid
hormone inhibition
hormone synthesis
male
nonhuman
phase partitioning
phospholipid synthesis
phospholipid transfer
protein function
rat
Adrenal Glands
Adrenocorticotropic Hormone
Alkaline Phosphatase
Animals
Bucladesine
Cells, Cultured
Enzyme Activation
Enzyme Inhibitors
Glycosylphosphatidylinositols
GTP-Binding Protein alpha Subunit, Gi2
GTP-Binding Protein alpha Subunits, Gi-Go
Inositol Phosphates
Male
Oligosaccharides
Polysaccharides
Proto-Oncogene Proteins
Rats
Rats, Sprague-Dawley
Signal Transduction
Trypanosoma
Trypanosoma cruzi
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03008177_v258_n1-2_p191_Martini
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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