Repeat proteins challenge the concept of structural domains

Structural domains are believed to be modules within proteins that can fold and function independently. Some proteins show tandem repetitions of apparent modular structure that do not fold independently, but rather co-operate in stabilizing structural forms that comprise several repeat-units. For ma...

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Detalles Bibliográficos
Autores principales: Espada, R., Parra, R.G., Sippl, M.J., Mora, T., Walczak, A.M., Ferreiro, D.U.
Formato: JOUR
Materias:
Ankyrin-repeat
Local frustration
Repeat-protein
protein
repeat protein
unclassified drug
Article
molecular evolution
physiological process
priority journal
protein analysis
protein domain
protein folding
amino acid sequence
animal
chemical structure
energy transfer
human
protein conformation
protein secondary structure
protein stability
protein tertiary structure
tandem repeat
Animals
Energy Transfer
Evolution, Molecular
Humans
Models, Molecular
Protein Conformation
Protein Folding
Protein Interaction Domains and Motifs
Protein Stability
Protein Structure, Secondary
Protein Structure, Tertiary
Repetitive Sequences, Amino Acid
Tandem Repeat Sequences
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_03005127_v43_n_p844_Espada
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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