Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting

The proopiomelanocortin (POMC) gene is expressed in the pituitary and arcuate neurons of the hypothalamus. POMC arcuate neurons play a central role in the control of energy homeostasis, and rare loss-of-function mutations in POMC cause obesity. Moreover, POMC is the prime candidate gene within a hig...

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Detalles Bibliográficos
Autores principales: De Souza, F.S.J., Santangelo, A.M., Bumaschny, V., Avale, M.E., Smart, J.L., Low, M.J., Rubinstein, M.
Formato: JOUR
Materias:
proopiomelanocortin
animal tissue
article
brain
controlled study
DNA footprinting
DNA polymorphism
gene deletion
genetic analysis
hypophysis
hypothalamus
mouse
nonhuman
phylogeny
priority journal
protein expression
protein localization
reporter gene
transgenic mouse
Animals
Arcuate Nucleus
Base Sequence
Conserved Sequence
DNA Mutational Analysis
Enhancer Elements (Genetics)
Gene Expression Regulation
Genes, Reporter
Green Fluorescent Proteins
Humans
Mice
Mice, Transgenic
Molecular Sequence Data
Neurons
Obesity
Phylogeny
Pituitary Gland, Anterior
Polymorphism, Genetic
Pro-Opiomelanocortin
Sequence Deletion
Mammalia
Mus musculus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02707306_v25_n8_p3076_DeSouza
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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