Study of phenformin metabolism in rat liver microsomes by HPLC, CE and on-line HPLC-electrospray ionization mass spectrometry

Methods for the analysis of phenformin and its metabolite by high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and high-performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-ESIMS) are developed. The effects of pH, buffer concentration and prop...

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Detalles Bibliográficos
Autores principales:	Llambias, E.B.C., Luo, J.
Formato:	JOUR
Materias:	phenformin animal cell article capillary electrophoresis concentration response controlled study drug metabolism high performance liquid chromatography incubation time ionization liver microsome mass spectrometry metabolic inhibition metabolite nonhuman ph rat Acetates Animals Buffers Chromatography, High Pressure Liquid Electrophoresis, Capillary Female Hydrogen-Ion Concentration Hypoglycemic Agents Mass Spectrometry Metformin Methanol Microsomes, Liver Online Systems Osmolar Concentration Phenformin Rats Spectrophotometry, Ultraviolet Time Factors Animalia
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_02693879_v10_n4_p155_Llambias
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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