Synthetic DAF-12 modulators with potential use in controlling the nematode life cycle

Dafachronic acids (DAs) are 3-keto cholestenoic acids bearing a carboxylic acid moiety at the end of the steroid side chain. These compounds interact with the DAF-12 receptor, a ligand-dependent transcription factor that acts as a molecular switch mediating the choice between arrest at diapause or p...

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Detalles Bibliográficos
Autores principales: Dansey, M.V., Alvarez, L.D., Samaja, G., Escudero, D.S., Veleiro, A.S., Pecci, A., Castro, O.A., Burton, G.
Formato: JOUR
Materias:
Caenorhabditis elegans
DAF-12 receptor
Daf-9 mutant
Dafachronic acid
Molecular dynamics
24 hydroxy 4 cholen 3 one
alcohol derivative
carboxylic acid derivative
dafachronic acid receptor 12
steroid
unclassified drug
Caenorhabditis elegans protein
cell receptor
cholestane derivative
DAF-12 protein, C elegans
dafachronic acid
ligand
animal experiment
Article
biological activity
concentration response
conformation
controlled study
developmental stage
HEK293 cell line
human
human cell
in vitro study
in vivo study
life cycle
luciferase assay
nonhuman
phenotype
quantum chemistry
transactivation
allele
animal
chemistry
drug effects
growth, development and aging
life cycle stage
metabolism
reporter gene
Nematoda
Alleles
Animals
Caenorhabditis elegans Proteins
Cholestenes
Genes, Reporter
HEK293 Cells
Humans
Life Cycle Stages
Ligands
Receptors, Cytoplasmic and Nuclear
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02646021_v465_n_p175_Dansey
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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