Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route

Forty-five GM1-binding peptides were identified using phage-displayed peptides libraries of random peptides. Most have a motif containing a hydrophobic amino acid followed by a serine (S). Based on a GM1-binding assays, two of these GM1-binding peptides (named 15 and 40) were chosen to investigate i...

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Detalles Bibliográficos
Autores principales: Montaner, A.D., De Nichilo, A., Elias, F., Rodríguez, J.M., Fló, J.M., López, R.A., Zorzopulos, J., Frank, R.
Formato: JOUR
Materias:
GM1-binding peptides
Mucosal adjuvants
Phage display
bromacetyl beta alanyl beta alanylarginylseryllysylprolylprolyleucylserylprolylleucylglycyltyrosinamide
bromacetyl beta alanyl beta alanylprolylprolylserylprolylserylvalylserylhistidylarginylthreonyltyrosinamide
ganglioside GM1
immunological adjuvant
peptide
peptide library
serine
unclassified drug
amino acid composition
animal cell
animal experiment
antibody response
article
binding assay
controlled study
immunostimulation
inoculation
mouse
nonhuman
phage display
priority journal
protein motif
Adjuvants, Immunologic
Administration, Intranasal
Animals
Antibodies, Bacterial
Antibodies, Viral
Antigens, Bacterial
Antigens, Viral
Bronchoalveolar Lavage Fluid
Cell Wall
Enzyme-Linked Immunosorbent Assay
G(M1) Ganglioside
Hemagglutinin Glycoproteins, Influenza Virus
Immunoglobulin A
Immunoglobulin G
Influenza Vaccines
Mice
Mice, Inbred BALB C
Neuraminidase
Peptide Library
Peptides
Protein Binding
Streptococcus pneumoniae
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0264410X_v24_n11_p1889_Montaner
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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