Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents

As part of our efforts aimed at searching for new antiparasitic agents, 2-alkylmercaptoethyl-1,1-bisphosphonate derivatives were synthesized and evaluated against Trypanosoma cruzi, the etiologic agent of Chagas disease, and Toxoplasma gondii, the responsible agent for toxoplasmosis. Many of these s...

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Detalles Bibliográficos
Autores principales: Recher, M., Barboza, A.P., Li, Z.-H., Galizzi, M., Ferrer-Casal, M., Szajnman, S.H., Docampo, R., Moreno, S.N.J., Rodriguez, J.B.
Formato: JOUR
Materias:
Antiparasitic agents
Chagas disease
Farnesyl diphosphate synthase
Toxoplasma gondii
Toxoplasmosis
Trypanosoma cruzi
1 [(ethylthio)ethyl] 1,1 bisphosphonic acid
1 [(n butylsulfinyl)ethyl] 1,1 bisphosphonic acid
1 [(n butylthio)ethyl] 1,1 bisphosphonic acid
1 [(n decylthio)ethyl] 1,1 bisphosphonic acid
1 [(n hept 2 ylamino)ethyl] 1,1 bisphosphonic acid
1 [(n heptylamino)ethyl] 1 hydroxy 1,1 bisphosphonic acid
1 [(n heptylsulfinyl)ethyl] 1,1 bisphosphonic acid
1 [(n heptylthio)ethyl] 1,1 bisphosphonic acid
1 [(n hexylsulfinyl)ethyl] 1,1 bisphosphonic acid
1 [(n hexylthio)ethyl] 1,1 bisphosphonic acid
1 [(n nonylthio)ethyl] 1,1 bisphosphonic acid
1 [(n octylsulfinyl)ethyl] 1,1 bisphosphonic acid
1 [(n octylthio)ethyl] 1,1 bisphosphonic acid
1 [(n pentylsulfinyl)ethyl] 1,1 bisphosphonic acid
1 [(n pentylthio)ethyl] 1,1 bisphosphonic acid
1 [(n propylthio)ethyl] 1,1 bisphosphonic acid
antiinfective agent
antiparasitic agent
bisphosphonic acid derivative
geranyltransferase
tetraethyl 1 [(ethylthio)ethyl] 1,1 bisphosphonate
tetraethyl 1 [(n but 1 ylthio)ethyl] 1,1 bisphosphonate
tetraethyl 1 [(n dec 1 ylthio)ethyl] 1,1 bisphosphonate
tetraethyl 1 [(n hept 1 ylthio)ethyl] 1,1 bisphosphonate
tetraethyl 1 [(n hex 1 ylthio)ethyl] 1,1 bisphosphonate
tetraethyl 1 [(n non 1 ylthio)ethyl] 1,1 bisphosphonate
tetraethyl 1 [(n oct 1 ylthio)ethyl] 1,1 bisphosphonate
tetraethyl 1 [(n pent 1 ylthio)ethyl] 1,1 bisphosphonate
tetraethyl 1 [(n prop 1 ylthio)ethyl] 1,1 bisphosphonate
unclassified drug
unindexed drug
amastigote
antimicrobial activity
article
carbon nuclear magnetic resonance
drug design
drug screening
drug structure
drug synthesis
enzyme activity
high performance liquid chromatography
nonhuman
oxidation
proton nuclear magnetic resonance
tachyzoite
toxoplasmosis
Antiprotozoal Agents
Diphosphonates
Dose-Response Relationship, Drug
Drug Design
Molecular Structure
Parasitic Sensitivity Tests
Structure-Activity Relationship
Sulfur
Toxoplasma
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_02235234_v60_n_p431_Recher
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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