The extrinsic and intrinsic apoptotic pathways are involved in manganese toxicity in rat astrocytoma C6 cells

Manganese (Mn) is a trace element known to be essential for maintaining the proper function and regulation of many biochemical and cellular reactions. However, chronic exposure to high levels of Mn in occupational or environmental settings can lead to its accumulation in the brain resulting in a deg...

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Detalles Bibliográficos
Autores principales: Alaimo, A., Gorojod, R.M., Kotler, M.L.
Formato: JOUR
Materias:
Apoptosis
C6 cells
Caspases
Manganese
Mitochondria
caspase 3
caspase 7
caspase 8
caspase 9
cytochrome c
Fas ligand
manganese
mitochondrial permeability transition pore
nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase
protein bcl 2
protein Bid
reactive oxygen metabolite
animal cell
apoptosis
article
astrocytoma cell
cell death
cell viability
chromatin condensation
controlled study
enzyme activation
mitochondrial membrane potential
mitochondrion
neurotoxicity
nonhuman
priority journal
protein cleavage
protein secretion
rat
signal transduction
Animals
Astrocytoma
Blotting, Western
Cell Line, Tumor
Microscopy, Fluorescence
Rats
Subcellular Fractions
Rattus
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01970186_v59_n2_p297_Alaimo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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