Delayed and bilateral changes of GAP-43/B-50 phosphorylation after circling training during a critical period in rat striatum

During the critical period of activity-dependent plasticity in rat striatum (30-37 days after birth) physiological circling behavior induces delayed modifications in GAP-43/B-50 phosphorylation by PKC. Postexercise, ipsi- and contralateral striatum to the circling direction show a similar temporal p...

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Detalles Bibliográficos
Autores principales: Azcurra, J.M., Soiza-Reilly, M., Fossati, M., Paratcha, G.Ch.
Formato: JOUR
Materias:
Circling training
Development
GAP-43/B-50
Motor activity
Plasticity
Striatum
neuromodulin
protein kinase C
animal tissue
article
brain level
circling behavior
controlled study
corpus striatum
enzyme activity
male
motor activity
nerve cell plasticity
nonhuman
priority journal
protein localization
protein modification
protein phosphorylation
rat
Animalia
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0169328X_v118_n1-2_p166_Azcurra
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:During the critical period of activity-dependent plasticity in rat striatum (30-37 days after birth) physiological circling behavior induces delayed modifications in GAP-43/B-50 phosphorylation by PKC. Postexercise, ipsi- and contralateral striatum to the circling direction show a similar temporal pattern of GAP-43/B-50 phosphorylation, with an initial decrease followed by a subsequent increase. However, there is a lag between initiation of the phosphorylation response in this asymmetrical task which does not occur when animals are subjected to exercise under conditions of symmetrical motor activity. © 2003 Elsevier B.V. All rights reserved.

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