CRE-Mediated transcriptional activation is involved in cAMP protection of T-cell receptor-induced apoptosis but not in cAMP potentiation of glucocorticoid-mediated programmed cell death

Apoptosis of thymic cells induced by glucocorticoids (GC) and T-cell receptor (TCR) engagement are mutually antagonistic. We demonstrate that cAMP enhances GC and antagonizes TCR (anti-CD3) apoptosis on the same cell (DO-11.10 and 2B4.11 T-cell hybridomas). We analyzed the activity of several transc...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Igaz, L.M., Refojo, D., Costas, M.A., Holsboer, F., Arzt, E.
Formato: JOUR
Materias:
Apoptosis
CAMP responsive element binding protein
Cyclic AMP
Glucocorticoids
T cell receptor
bucladesine
CD3 antigen
cyclic AMP
cyclic AMP responsive element binding protein
dexamethasone
DNA
glucocorticoid
immunoglobulin enhancer binding protein
monoclonal antibody CD3
oligomer
T lymphocyte receptor
animal cell
apoptosis
article
controlled study
cyclic AMP responsive element
enzyme activity
enzyme inhibition
genetic transfection
hybridoma cell culture
mouse
nonhuman
priority journal
regulatory mechanism
T lymphocyte
transcription initiation
Animals
Cell Line
Cyclic AMP Response Element-Binding Protein
Flow Cytometry
Hybridomas
Mice
Receptors, Antigen, T-Cell
Response Elements
T-Lymphocytes
Transcription, Genetic
Transfection
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01674889_v1542_n1-3_p139_Igaz
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Ejemplares similares

Ejemplares similares