Host Epac1 is required for cAMP-mediated invasion by Trypanosoma cruzi

Mechanistic details of the modulation by cAMP of Trypanosoma cruzi host cell invasion remain ill-defined. Here we report that activation of host's Epac1 stimulated invasion, whereas specific pharmacological inhibition or maneuvers that alter Epac1 subcellular localization significantly reduced...

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Detalles Bibliográficos
Autores principales: Musikant, D., Ferri, G., Durante, I.M., Buscaglia, C.A., Altschuler, D.L., Edreira, M.M.
Formato: JOUR
Materias:
cAMP
Epac
Invasion
PKA
Trypanosoma cruzi
cyclic AMP
cyclic AMP dependent protein kinase
Epac1 protein
protozoal protein
unclassified drug
Epac-1 protein, rat
guanine nucleotide exchange factor
Article
cellular distribution
host cell
nonhuman
priority journal
protein localization
protein synthesis
signal transduction
animal
cell culture
host parasite interaction
metabolism
pathogenicity
physiology
protein transport
rat
Animals
Cells, Cultured
Cyclic AMP
Cyclic AMP-Dependent Protein Kinases
Guanine Nucleotide Exchange Factors
Host-Parasite Interactions
Protein Transport
Rats
Signal Transduction
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01666851_v211_n_p67_Musikant
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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