TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi

Cyclic nucleotide phosphodiesterases constitute the only known mechanism to inactivate regulatory signals involving cAMP or cGMP. In our laboratory a cAMP-specific phosphodiesterase associated to the flagellar apparatus, named TcPDE1, was identified in Trypanosoma cruzi. By using the catalytic domai...

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Detalles Bibliográficos
Autores principales: Alonso, G.D., Schoijet, A.C., Torres, H.N., Flawiá, M.M.
Formato: JOUR
Materias:
cAMP
FYVE domain
Phosphatidylinositol 3-phosphate
Rolipram
detergent
etazolate
membrane protein
phosphatase
phosphatidylinositol 3 phosphate
phosphodiesterase IV
protozoal protein
rolipram
sodium chloride
amino acid sequence
article
cell compartmentalization
cell membrane
concentration (parameters)
enzyme active site
enzyme inhibition
enzyme specificity
eukaryotic flagellum
extraction
gene
genetic conservation
genome analysis
IC 50
nonhuman
nucleotide sequence
priority journal
protein analysis
protein family
screening
sequence analysis
sequence homology
temperature sensitive mutant
Trypanosoma cruzi
vertebrate
zinc finger motif
3',5'-Cyclic-Nucleotide Phosphodiesterase
Amino Acid Sequence
Animals
Base Sequence
Cell Membrane
Cloning, Molecular
DNA, Protozoan
Etazolate
Kinetics
Molecular Sequence Data
Phosphodiesterase Inhibitors
Recombinant Proteins
Sequence Alignment
Eukaryota
Vertebrata
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01666851_v145_n1_p40_Alonso
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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