Aesculus hippocastanum L. seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung inflammation in vivo

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease and bronchiolitis in children worldwide. No vaccine or specific, effective treatment is currently available. β-escin is one of the main bioactive constituents of Aesculus hippocastanum L. (Hippocastanaceae) seed...

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Detalles Bibliográficos
Autores principales: Salinas, F.M., Vázquez, L., Gentilini, M.V., O´Donohoe, A., Regueira, E., Nabaes Jodar, M.S., Viegas, M., Michelini, F.M., Hermida, G., Alché, L.E., Bueno, C.A.
Formato: JOUR
Materias:
Aesculus hippocastanum
Antiviral
Immunomodulatory
Medicinal plants
Respiratory syncytial virus (RSV)
β-escin
Aesculus hippocastanum extract
beta actin
beta escin
gamma interferon
immunoglobulin enhancer binding protein
interleukin 17
interleukin 4
interleukin 6
interleukin 8
transcription factor AP 1
tumor necrosis factor
virus RNA
animal cell
animal experiment
animal model
animal tissue
antiviral activity
Article
controlled study
epithelium cell
human
human cell
immunomodulation
in vitro study
lung epithelium
lung parenchyma
macrophage
mouse
nonhuman
plant seed
priority journal
respiratory syncytial virus infection
respiratory tract inflammation
RNA replication
signal transduction
Th2 cell
treatment duration
Vero cell line
virucidal activity
virus infectivity
virus load
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01663542_v164_n_p1_Salinas
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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