Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin

Receptors for insulin and insulin-like growth factor-1 (IGF-1) have been demonstrated on activated T-lymphocytes. The question is whether receptors for insulin or IGF-1 have any function in these cells. In this study we demonstrate that the concentration of IGF-1 in commercial samples of fetal calf...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Roldan, A., Charreau, E., Schillaci, R., Eugui, E.M., Allison, A.C.
Formato: JOUR
Materias:
Fetal calf serum
Human peripheral blood mononuclear cells
Insulin-like growth factor-1 (IGF-1)
Mitogenic response
growth factor
insulin
mitogenic agent
phytohemagglutinin
cell culture
human
human cell
normal human
peripheral lymphocyte
priority journal
t lymphocyte
Animal
Antibodies
Cattle
Cell Division
Fetal Blood
Human
Insulin-Like Growth Factor I
Lymphocyte Activation
Phytohemagglutinins
Receptors, Cell Surface
Receptors, Somatomedin
Recombinant Proteins
Somatomedins
Stimulation, Chemical
Support, Non-U.S. Gov't
T-Lymphocytes
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01652478_v20_n1_p5_Roldan
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Receptors for insulin and insulin-like growth factor-1 (IGF-1) have been demonstrated on activated T-lymphocytes. The question is whether receptors for insulin or IGF-1 have any function in these cells. In this study we demonstrate that the concentration of IGF-1 in commercial samples of fetal calf serum is about 70 times that of insuli. Moreover, antibodies of IGF-1 reduce responses of human peripheral blood mononuclear cells to PHA by about 50% whereas antibodies to insulin have no demonstrable effect. These observations suggest that binding of IGF-1 to specific receptors contributes to the proliferative responses of activated T-lymphocytes. © 1989.

Ejemplares similares