Mechanisms involved in p53 downregulation by leptin in trophoblastic cells

Leptin, a 16-kDa polypeptide hormone, is produced by the adipocyte and can also be synthesized by placenta. We previously demonstrated that leptin promotes proliferation and survival in placenta, in part mediated by the p53 pathway. In this work, we investigated the mechanisms involved in leptin dow...

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Detalles Bibliográficos
Autores principales: Toro, A.R., Pérez-Pérez, A., Corrales Gutiérrez, I., Sánchez-Margalet, V., Varone, C.L.
Formato: JOUR
Materias:
Anti-apoptotic effect
Leptin
MAPK and PI3K signal transduction pathways
MDM-2
p53
Placenta
2 (2 amino 3 methoxyphenyl)chromone
leptin
ly 29004
mitogen activated protein kinase
phosphatidylinositol 3 kinase
protein inhibitor
protein p53
unclassified drug
protein MDM2
apoptosis
Article
DNA fragmentation
down regulation
enzyme activity
explant
first trimester pregnancy
half life time
human
human cell
human tissue
priority journal
protein phosphorylation
reverse transcription polymerase chain reaction
signal transduction
transient transfection
trophoblast
Western blotting
cell line
cell proliferation
metabolism
Apoptosis
Cell Line
Cell Proliferation
Humans
MAP Kinase Signaling System
Phosphatidylinositol 3-Kinases
Proto-Oncogene Proteins c-mdm2
Trophoblasts
Tumor Suppressor Protein p53
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_01434004_v36_n11_p1266_Toro
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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