Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors

The clinical benefit conferred by vascular endothelial growth factors (VEGF)-targeted therapies is variable, and tumors from treated patients eventually reinitiate growth. Here, we identify a glycosylation-dependent pathway that compensates for the absence of cognate ligand and preserves angiogenesi...

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Detalles Bibliográficos
Autores principales:	Croci, D.O., Cerliani, J.P., Dalotto-Moreno, T., Méndez-Huergo, S.P., Mascanfroni, I.D., Dergan-Dylon, S., Toscano, M.A., Caramelo, J.J., García-Vallejo, J.J., Ouyang, J., Mesri, E.A., Junttila, M.R., Bais, C., Shipp, M.A., Salatino, M., Rabinovich, G.A.
Formato:	JOUR
Materias:	Angiogenesis Inhibitors Animals Anoxia Endothelial Cells Galectin 1 Glycosylation Humans Mice Neoplasms Neovascularization, Pathologic Receptors, Mitogen Vascular Endothelial Growth Factors galectin 1 lectin receptor ligand sialic acid vasculotropin vasculotropin antibody vasculotropin receptor 2 angiogenesis animal experiment animal model animal tissue Article breast metastasis cancer inhibition controlled study depletion drug efficacy endothelium cell gene silencing glycosylation human human cell hypoxia immunocompetent cell kidney carcinoma liver cell carcinoma metastatic colorectal cancer mouse neoplasm non small cell lung cancer nonhuman protein binding protein secretion vascularization
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_00928674_v156_n4_p744_Croci
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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