Antibodies bind and activate β adrenergic and cholinergic lymphocyte receptors in Chagas' disease
It is demonstrated that murine chagasic IgG and the corresponding F(ab′)2 fragments interfere with β adrenergic and muscarinic cholinergic specific ligand occupancy on T cell-enriched population. From the interaction between chagasic IgG or F(ab′)2 with Lyt-1+ cells, an increase in cAMP levels occur...
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| Autores principales: | , , , , |
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00901229_v55_n2_p221_Gorelik |
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| Sumario: | It is demonstrated that murine chagasic IgG and the corresponding F(ab′)2 fragments interfere with β adrenergic and muscarinic cholinergic specific ligand occupancy on T cell-enriched population. From the interaction between chagasic IgG or F(ab′)2 with Lyt-1+ cells, an increase in cAMP levels occurs as a consequence of β adrenergic receptor activation. On the contrary, chagasic IgG or F(ab′)2 interactions with Lyt-2+ cells induce an activation of muscarinic cholinergic receptor, leading to an increment in cGMP. Muscarinic cholinergic and β adrenergic stimulation trigger the release of PGE2 and TXB2, respectively. Lyt-2+ cells treated with chagasic IgG or F(ab′)2 are able to decrease the contractility of mouse atria. The same negative inotropic effect is elicited with Lyt-2+ cells from Trypanosoma cruzi-infected mice susceptible to developed myocarditis. The implications of these results in the pathogenesis of Chagas' myocarditis are discussed. © 1990. |
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