External guide sequence technology: A path to development of novel antimicrobial therapeutics

RNase P is a ribozyme originally identified for its role in maturation of tRNAs by cleavage of precursor tRNAs (pre-tRNAs) at the 5′-end termini. RNase P is a ribonucleoprotein consisting of a catalytic RNA molecule and, depending on the organism, one or more cofactor proteins. The site of cleavage...

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Detalles Bibliográficos
Autores principales: Davies-Sala, C., Soler-Bistué, A., Bonomo, R.A., Zorreguieta, A., Tolmasky, M.E.
Formato: JOUR
Materias:
Antimicrobials
Antisense
Drug design
External guide sequence
RNase P
aminoglycoside 6' n acetyltransferase type Ib
antibiotic agent
bacterial enzyme
FtsZ protein
messenger RNA
ribonuclease P
unclassified drug
antiinfective agent
antisense oligonucleotide
bacterial RNA
ribozyme
antibiotic resistance
Article
bacterial infection
Brucella melitensis
Cytomegalovirus
enzyme inhibition
Escherichia coli
external guide sequence
Francisella tularensis
gene expression
genetic procedures
Hepatitis B virus
human
Human immunodeficiency virus
Influenza virus
nonhuman
protein cleavage
protein targeting
Salmonella enterica serovar Typhimurium
virus
virus infection
Yersinia pestis
Bacterial Infections
bacterium
biological model
chemistry
conformation
drug effects
genetics
metabolism
microbiology
Anti-Bacterial Agents
Bacteria
Humans
Models, Genetic
Nucleic Acid Conformation
Oligoribonucleotides, Antisense
Ribonuclease P
RNA, Bacterial
RNA, Catalytic
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00778923_v1354_n1_p98_DaviesSala
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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