Terpenes arrest parasite development and inhibit biosynthesis of isoprenoids in Plasmodium falciparum

Development of new drugs is one of the strategies for malaria control. The biosynthesis of several isoprenoids in Plasmodiumfalciparum was recently described. Interestingly, some intermediates and final products biosynthesized by this pathway in mammals differ from those biosynthesized in P. falcipa...

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Detalles Bibliográficos
Autores principales: Goulart, H.R., Kimura, E.A., Peres, V.J., Couto, A.S., Duarte, F.A.A., Katzin, A.M.
Formato: JOUR
Materias:
antimalarial agent
farnesol
farnesylthiosalicylic acid
fosmidomycin
isoprenoid
limonene
linalool
nerolidol
terpene derivative
antimalarial activity
article
biosynthesis
concentration response
controlled study
developmental stage
malaria
malaria control
minimum inhibitory concentration
nonhuman
parasite development
Plasmodium falciparum
priority journal
protein synthesis
schizont
steroidogenesis
trophozoite
Animals
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Depression, Chemical
Dolichol
Electrophoresis, Polyacrylamide Gel
Erythrocytes
Farnesol
Lipid Metabolism
Malaria, Falciparum
Precipitin Tests
Salicylic Acids
Terpenes
Ubiquinone
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00664804_v48_n7_p2502_Goulart
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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