Platelet function and antithrombins in hyperlipoproteinemia type IIa
Platelet function was studied in 35 patients with type IIa hyperlipoproteinemia and 22 normal controls. Platelet aggregation by ADP in concentrations ranging from 2×10-6 to 2×10-5 M, and adrenaline 10-6 M were similar in both groups. In contrast, aggregation induced by collagen and secondary aggrega...
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| Autores principales: | , , , , |
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_00493848_v22_n4_p427_Molinas |
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| Sumario: | Platelet function was studied in 35 patients with type IIa hyperlipoproteinemia and 22 normal controls. Platelet aggregation by ADP in concentrations ranging from 2×10-6 to 2×10-5 M, and adrenaline 10-6 M were similar in both groups. In contrast, aggregation induced by collagen and secondary aggregation elicited by bovine factor VIII were significantly lower in hypercholesterolemic patients, who also disclosed an increased plasmatic antiheparin activity. This plasmatic antiheparin activity was inversely correlated to plasmatic cholesterol concentration, (r = -0.50, p<0.01). PF3 and PF4 were normal in patients with type IIa hyperlipoproteinemia. AntiFXa, antithrombin III, and heparin cofactor were also determined. Heparin cofactor was found to be significantly lower in hypercholesterolemic patients than in controls, and inversely correlated to plasmatic cholesterol concentration (r = -0.51, p<0.05). These observations suggest that the thrombotic tendency in hypercholesterolemia may be related to a decrease of plasmatic heparin cofactor. © 1981. |
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