Comparative toxicity of two glyphosate-based formulations to Eisenia andrei under laboratory conditions

Glyphosate-based products are the leading post-emergent agricultural herbicides in the world, particularly in association with glyphosate tolerant crops. However, studies on the effects of glyphosate-based formulations on terrestrial receptors are scarce. This study was conducted to evaluate the com...

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Detalles Bibliográficos
Autores principales: Piola, L., Fuchs, J., Oneto, M.L., Basack, S., Kesten, E., Casabé, N.
Formato: JOUR
Materias:
Comet assay
Eisenia andrei
Glyphosate formulations
Neutral red retention time
Sublethal biomarkers
Comet assays
Ecotoxicological assessment
Environmental concentration
Glyphosates
Median Lethal concentration
Oxidative phosphorylation
Retention time
Agriculture
Biochemistry
Toxicity
Herbicides
ammonium derivative
glyphosate
agricultural practice
bioavailability
biomarker
comparative study
concentration (composition)
dose-response relationship
earthworm
ecotoxicology
laboratory method
pollution effect
toxicity test
weight
article
bioaccumulation
cell damage
comet assay
controlled study
DNA damage
growth
LC 50
lysosome
nonhuman
oxidative phosphorylation
toxicity
weight reduction
Animals
Glycine
Laboratories
Lethal Dose 50
Oligochaeta
Risk Assessment
Soil Pollutants
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_00456535_v91_n4_p545_Piola
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Glyphosate-based products are the leading post-emergent agricultural herbicides in the world, particularly in association with glyphosate tolerant crops. However, studies on the effects of glyphosate-based formulations on terrestrial receptors are scarce. This study was conducted to evaluate the comparative toxicity of two glyphosate-based products: Roundup FG (monoammonium salt, 72% acid equivalent, glyphosate-A) and Mon 8750 (monoammonium salt, 85.4% acid equivalent, glyphosate-B), towards the earthworm Eisenia andrei. Median lethal concentration (LC50) showed that glyphosate-A was 4.5-fold more toxic than glyphosate-B. Sublethal concentrations caused a concentration-dependent weight loss, consistent with the reported effect of glyphosate as uncoupler of oxidative phosphorylation. Glyphosate-A showed deleterious effects on DNA and lysosomal damage at concentrations close to the applied environmental concentrations (14.4μg ae cm-2). With glyphosate-B toxic effects were observed at higher doses, close to its LC50, suggesting that the higher toxicity of formulate A could be attributed to the effects of some of the so-called "inert ingredients", either due to a direct intrinsic toxicity, or to an enhancement in the bioavailability and/or bioaccumulation of the active ingredient. Our results highlight the importance of ecotoxicological assessment not only of the active ingredients, but also of the different formulations usually employed in agricultural practices. © 2012 Elsevier Ltd.

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