Antitumor effectiveness of a combined therapy with a new cucurbitacin B derivative and paclitaxel on a human lung cancer xenograft model

Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors, with a high mortality rate due to the elevated risk of resistance. Natural cucurbitacins and their derivatives are recognized as promising antitumor compounds for several types of cancer, including NSCLC. In a recent stud...

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Detalles Bibliográficos
Autores principales: Marostica, L.L., de Barros, A.L.B., Oliveira, J., Salgado, B.S., Cassali, G.D., Leite, E.A., Cardoso, V.N., Lang, K.L., Caro, M.S.B., Durán, F.J., Schenkel, E.P., de Oliveira, M.C., Simões, C.M.O.
Formato: JOUR
Materias:
Antitumor effect
Cucurbitacins
Lung cancer
Paclitaxel
Scintigraphic images
Xenograft lung tumor
2 deoxy 2 amine cucurbitacin E
cucurbitacin
paclitaxel
unclassified drug
antineoplastic agent
cucurbitacin B
Ki 67 antigen
radiopharmaceutical agent
triterpene
animal experiment
animal model
antineoplastic activity
antiproliferative activity
cancer inhibition
cancer size
chronic toxicity
combination chemotherapy
controlled study
drug efficacy
drug potentiation
drug screening
drug tolerability
female
human
human cell
immunohistochemistry
in vivo study
mouse
non small cell lung cancer
nonhuman
Review
scintigraphy
tumor xenograft
A-549 cell line
animal
Bagg albino mouse
Carcinoma, Non-Small-Cell Lung
cell proliferation
diagnostic imaging
drug effects
Lung Neoplasms
metabolism
nude mouse
pathology
time factor
toxicity testing
tumor volume
whole body imaging
A549 Cells
Animals
Antineoplastic Combined Chemotherapy Protocols
Cell Proliferation
Female
Humans
Ki-67 Antigen
Mice, Inbred BALB C
Mice, Nude
Radiopharmaceuticals
Time Factors
Toxicity Tests, Subchronic
Triterpenes
Tumor Burden
Whole Body Imaging
Xenograft Model Antitumor Assays
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_0041008X_v329_n_p272_Marostica
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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