Cholinesterase inhibition by phenothiazine and nonphenothiazine antihistaminics: Analysis of its postulated role in synergizing organophosphate toxicity
Several antihistaminic compounds inhibit in vitro pseudocholinesterase (ChE) from several sources (human, rat, or horse plasma), pI50 ranging from 5.0 to 6.0. This inhibition is competitive with acetylcholine (ACh) and is reversible. Acetylcholinesterase (AChE) from rat brain was nonsensitive to ant...
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| Autores principales: | , , |
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_0041008X_v31_n2_p179_Fernandez |
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